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Aerosols Containing Beclomethasone Nanoparticle Dispersions

Aerosols Containing Beclomethasone Nanoparticle Dispersions

Feb 23, 1996 Aerosols containing beclomethasone nanoparticle dispersions PAT - EP1354583 Wiedmann ... There is disclosed an aerosol comprising droplets of an aqueous dispersion of nanoparticles, said nanoparticles comprising insoluble beclomethazone particles having a surface modifier on the surface thereof. There is also disclosed a method for making the ...

Ep0810853a1 Aerosols Containing Nanoparticle Dispersions

There is disclosed an aerosol comprising droplets of an aqueous dispersion of nanoparticles, said nanoparticles comprising insoluble therapeutic or diagnostic agent particles having a surface modifier on the surface thereof. There is also disclosed a method for making the aerosol and methods for treatment and diagnosis using the aerosol.

Aerosols Containing Beclomethazone Nanoparticle Dispersions

An aerosol of an aqueous dispersion of nanoparticles, wherein the nanoparticles comprise 0.1 to 60 ww of insoluble beclomethasone particles having 1 an average particle size of less than about 400 nm, and 2 0.1 to 90 ww of a surface modifier adsorbed on the surface thereof.

Nebulized Aerosols Containing Nanoparticle Dispersions

Oct 09, 1997 Nebulized aerosols containing nanoparticle dispersions . United States Patent 6264922 ... Nanoparticles of beclomethasone diproprionate in 2.5 polyvinyl alcohol had a particle size distribution of 0.26 0.13 micrometer. This size remained constant throughout the course of the study neither was there any evidence of chemical instability. ...

Jp2007314581a Aerosols Containing Nanoparticle

PROBLEM TO BE SOLVED To provide aerosols containing nanoparticle dispersions. SOLUTION There is disclosed an aerosol comprising droplets of an aqueous dispersion of nanoparticles, the nanoparticles comprising insoluble therapeutic or diagnostic agent particles having a surface modifier on the surface thereof. There is also disclosed a method for making the aerosol and methods for

De69637288t2 Beclomethasone Nanoparticle Dispersions

Beclomethasone nanoparticle dispersions containing aerosols Download PDF Info ... Authority DE Germany Prior art keywords aerosol beclomethasone modifier particles rhinitis Prior art date 1995-02-24 Legal status The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no ...

Preparation Of Polymeric Nanoparticles Containing

Sep 16, 2003 Polymeric drug-containing nanoparticles were prepared using a novel aerosol flow reactor method. The polymeric drug-containing nanoparticles prepared consist of a poorly water soluble corticosteroid, beclomethasone dipropionate, and polymeric materials Eudragit E

Aerosols Containing Beclomethazone

Feb 23, 1996 There is disclosed an aerosol comprising droplets of an aqueous dispersion of nanoparticles, said nanoparticles comprising insoluble beclomethazone particles having a surface modifier on the surface thereof. There is also disclosed a method for making the aerosol and methods for treatment using the aerosol.

Us5747001a Aerosols Containing Beclomethazone

There is disclosed an aerosol comprising droplets of an aqueous dispersion of nanoparticles, said nanoparticles comprising insoluble beclomethazone particles having a surface modifier on the surface thereof. There is also disclosed a method for making the aerosol and methods for treatment using the aerosol.

Aerosols Containing Beclomethazone

3. The aerosol of claim I or the method of claim 2, wherein the beclomethasone particles have an effective average particle size of less than 300 nm, less than 250 nm or less than 100 nm. 4. The aerosol or the method of any preceding claim, wherein said nanoparticles comprise 0.1 to 60 ww of beclomethasone particles. 5.

An Invitro Assessment Of A Nanocrystal Beclomethasone

Short duration ultrasonic nebulization of a concentrated NanoCrystal colloidal dispersion of beclomethasone dipropionate demonstrated an increased respirable fraction and decreased throat deposition when evaluated in an Andersen 8-stage cascade impactor in comparison to the commercially available propellant-based product Vanceril. An aqueous-based 1.25 ww colloidal dispersion of ...

Amorphous Cyclosporin Nanodispersions For Enhanced

Nov 01, 2008 The precipitation process used to produce nanoparticle dispersions of CsA was based on previously established methods. 59, 62 Deionized DI water 50 g containing an appropriate amount of polysorbate 80 constituted the antisolvent phase into which 15 g of methanol containing 3.2 ww CsA was injected. Vacuum distillation was used to reduce ...

Preparation Of Nanoparticles Consisting Of Methacrylic

Figure 2.Schematic representation of a model depicting the dissolution process 113.. Figure 3.Diagrammatic representation of a solid carboxylic acid, HA, dissolving into a reactive medium containing h ydroxide ion and buffer components B and BH with a Nernst diffusion layer existing between the solid and the bulk solution. Sink conditions exist in the bulk solution, and the products, BH ...

Iloprostcontaining Liposomes For Aerosol Application In

Dec 27, 2006 Purpose Pulmonary arterial hypertension PAH is a severe and progressive disease. The prostacyclin analogue iloprost is effective against PAH, but requires six to nine inhalations per day. The feasibility of liposomes to provide a sustained release formulation to reduce inhalation frequency is evaluated from a technological point of view. Methods Liposomal formulations consisting of di ...

Beclomethasone And Betamethasone Drug Formulation

Jun 04, 2021 3-5 m needed for lung deposition. Additionally, the Beclovent Aerosol for Inhalation contains ozone-depleting chlorofluorocarbons which are being phased out of production 14. Other pMDI formulations of beclomethasone have been reported which do not contain ozone-depleting chlorofluorocarbons.

Drug Release From Nanoparticles Embedded In Four Different

Sep 27, 2013 Beclomethasone dipropionate was used as a model poorly soluble compound and nanoparticles of the drug were prepared with a simple precipitation method Galindo-Rodriguez et al., 2004, Matteucci et al., 2006, Valo et al., 2010, Wang et al., 2007. The role of the cellulose matrix is evaluated in order to see whether the origin of this ...

Nanomaterials Free Fulltext Loading Of Beclomethasone

Beclomethasone dipropionate in dispersion or loaded in liposomes, mucin-liposomes or hyalurosomes was not able to counteract the ROS production caused by the cigarette smoke extract on epithelial bronchial cells. Indeed, the values were still 100 p 0.05

Powder Or Dust Containing Patents And Patent Applications

Powder Or Dust Containing Patents Class 42446 Methods of hydrating lung mucous secretions with benzamil or phenamil. Patent number 5876700 Abstract Methods of hydrating lung mucous secretions in the lungs of a subject are disclosed. The methods involve administering benzamil or phenamil to the lungs of the subject in an amount effective to ...

Aerosol Containing Carbon Definition English

Cigarettes produce an aerosol containing over 4,000 chemical compounds, including nicotine, carbon monoxide, acrolein, and oxidant substances. LASER-wikipedia2 The aerosols contain about 90 sulfur and the rest is carbon , which makes the haze reddish in color.

Delivery By Dendritic Mesoporous Silica Nanoparticles

Jun 17, 2021 The activity of the antimicrobial peptide NapFab against intracellular Mycobacterium tuberculosis Mtb is significantly increased by loading onto dendritic mesoporous silica nanoparticles

Shortterm Rat Inhalation Study With Aerosols Of Acrylic

Short-term rat inhalation study with aerosols of acrylic ester-based polymer dispersions containing a fraction of nanoparticles Int J Toxicol . Jan-Feb 201231146-57. doi 10.11771091581811424778.

Beclomethasone And Betamethasone Drug Formulation

Jun 04, 2021 Beclomethasone and betamethasone are two very closely related glucocorticoid immunosuppressants with identical structures, except in betamethasone, the heteroatom substituent on the steroidal backbone is fluorine 12, while in beclomethasone, the heteroatom substituent is chlorine 13.

Shortterm Rat Inhalation Study With Aerosols Of Acrylic

Jan 19, 2012 These dispersions contain an anionic surfactant as an emulsifier. The content of volatile compounds was tested by gas chromatography. Total volatiles found in the dispersions were up to 0.2 weightweight ww of the test material and mainly consisted of alkyl alcohols, for example ethylhexanol and methanol, and esters, as ethylhexylacetate.

Us Patent For Nanoparticulate Dispersions Comprising A

Feb 15, 2002 Disclosed are solid dose nanoparticulate compositions comprising a poorly soluble active agent, at least one polymeric surface stabilizer, and dioctyl sodium sulfosuccinate DOSS. The solid dose compositions exhibit superior redispersibility of the nanoparticulate composition upon administration to a mammal, such as a human or animal. The invention also describes methods of making and using ...

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